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It provides a comprehensive look at how physiological systems often deviate from simple linear models.

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Michael Khoo’s approach is unique because it doesn't just describe biological processes; it models them using classical and modern control theory. The book is a staple in Biomedical Engineering (BME) curricula for several reasons:

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Using Root Locus and Nyquist plots to determine if a physiological system (like a pupillary light reflex) remains stable or enters a state of oscillation (pathology).

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Since Khoo’s work often involves MATLAB simulations, a good guide ensures that the numerical methods used to solve these systems are applied correctly. Key Topics Covered in the Manual