The document, titled Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria , is a specialized guideline developed by the Clinical and Laboratory Standards Institute (CLSI) . It serves as a critical extension to the primary antimicrobial susceptibility testing (AST) standards, specifically covering organisms that are not included in the more common CLSI M100 supplement. Core Purpose and Scope
: Detailed instructions for performing broth microdilution and agar disk diffusion for specific "non-standard" organisms. clsi document m45 pdf
: "Breakpoints" (susceptible, intermediate, or resistant) tailored to the unique growth characteristics of these bacteria. The document, titled Methods for Antimicrobial Dilution and