Portable versions are often missing critical DLL files or registry entries. This leads to frequent crashes, corrupted save files, and "Error 16" messages that can be nearly impossible to fix.
Most "free" portable versions are bundled with malicious code. Since you have to disable your antivirus to run many of them, you leave your system vulnerable to keyloggers (which steal passwords) or ransomware. adobe illustrator cs5 portable free link
Adobe now offers a streamlined version of Illustrator that runs in your browser, providing some portability without the risk of malware. Portable versions are often missing critical DLL files